Christopher R. Burtner

Research Interests

Dr. Burtner leads the Molecular Longevity Laboratory at RWU. The group uses the model organisms Saccharomyces cerevisiae (baker’s yeast) and Caenorhabditis elegans (土壤线虫)来了解调节细胞和有机体寿命的遗传和生化途径. 实验室目前的研究主要集中在三个主要目标上:

1. 阐明饮食限制对长寿的生化机制.
2. 确定长寿基因在酵母菌和线虫之间的保守程度, 并评估保守长寿通路对蛋白质毒性神经退行性模型的影响.
3. Develop CRISPR systems in yeast and C. elegans 探讨基因过表达对寿命的影响.

访问外部分子长寿实验室网站.

Awards & Certificates

Certificate of Distinction in Teaching
哈佛大学博克教与学中心(2017)

ABLConnect Teaching Innovator Prize
Harvard University (2017)

Science Teaching Experience for Postdocs
University of Washington (Certificate, 2015)

HHMI分子医学学者，医学进入研究生计划
University of Washington (Certificate, 2010)

Publications

Hollenhorst, MA, Braun, DA, Burtner, CR， Cajigas, I, Cunningham-Bussel, AC, Eser, PO, Nabel, CS, Tsai, FD, Michel, T和Yialamas, MA. 弥合鸿沟:在基础科学和临床医学的界面上的学生大查房的发展. Acad Med. 2019 (manuscript in submission).

Humbert, O, Chan, F, Rajawat, YS, Torgerson, T, Burtner, C, Hubbard, N, Humphrys, D, Nogaard, ZK, O’Donnell, P, Adair, JE, Trobridge, GD, Scharenberg, AM, Felsburg, PJ, Rawlings, DJ, Kiem, HP. G-CSF/AMD3100动员和体内基因治疗后SCID-X1犬的快速免疫重建. Blood Adv. 2018 May 8;2(9): 987 - 999.

Burtner, CR，钱德拉塞卡兰，D，桑托斯，EB，比尔德，BC，阿代尔，JE，桑德迈尔，BM，基姆，惠普. 基于天冬氨酸偶联单克隆CD45抗体的干细胞基因治疗非清髓调节. Hum Gene Ther. 2015 Jun;26(6):399 - 406.

Felsburg, P, Ravin, S, Malech, H, Sorrentino, B, Burtner, C, Kiem, H-P. 犬x连锁严重联合免疫缺陷模型的基因治疗研究. Hum Gene Ther Clin Dev. 2015 Mar;26(1):50 - 56.

Burtner, CR, Beard, BC, Kennedy, DR, Wohlfahrt, ME, Adair, JE, Trobridge, GD, Scharenberg, AM, Torgerson, TR, Rawlings, DJ, Felsburg, PJ, and Kiem, H-P. 静脉注射泡沫病毒载体纠正犬SCID-X1. Blood. 2014 Jun 5;123(23): 3578 - 3584.

Kiem, H-P, Arumugam, PI, Burtner, CR， Fox, C, Beard, BC, Dexheimer, P, Adair, JE, Malik, P. 以短尾猕猴为实验对象，研究慢病毒载体介导的基因治疗血红蛋白病的安全性和有效性. Mol TherMethods Clin Dev. 2014 Dec 17;1:14055.

Burtner, CR， Murakami, CJ, Olsen, B, Kennedy, BK, Kaeberlein, M. 芽殖酵母年代性长寿因素的基因组分析. Cell Cycle. 2011 May 1;10(9): 1385 - 1396.

Burtner, CR and Kennedy, BK. Progeria syndromes and ageing: what is the connection? Nat Rev Mol Cell Biol. 2010 Aug;11(8): 567 - 578.

Burtner, CR, Murakami, CJ, Kennedy, BK, and Kaeberlein, M. A molecular mechanism of chronological aging in yeast. Cell Cycle. 2009 Apr 15;8(8): 1256 - 1270.

Burtner, CR, Murakami, CJ, and Kaeberlein, M. A genomic approach to yeast chronological aging. Methods Mol Biol. 2009;548: 101 - 114.

Kudlow, BA, Stanfel, MN, Burtner, CR, Johnston, ED, and Kennedy, BK. 通过hTERT或p53失活抑制与加工缺陷lamin A突变体相关的增殖缺陷. Mol Biol Cell. 2008 Dec;19(12): 5238 - 5248.

Murakami, CJ, Burtner, CR, Kennedy, BK, and Kaeberlein, M. 酵母时间顺序寿命的高通量定量分析方法. J Gernotol A Biol Sci Med Sci. 2008 Feb;63(2): 113 - 121.

Kaeberlein, M, Burtner, CR, and Kennedy, BK. Recent developments in yeast aging. PLoS Genet. 2007 May 25;3(5):e84.

Till, BJ, Reynolds, SH, Weil, C, Springer, N, Burtner, C， Young, K, Bowers, E, Codomo, CA, Enns, LC, Odden, AR和Henikoff, S. 利用TILLING技术发现玉米基因诱导点突变. BMC Plant Biol. 2004 Jul 28; 4:12.

Till, BJ, Burtner, C, Comai, L, and Henikoff, S. Mismatch cleavage by single-strand specific nucleases. Nucleic Acids Res. 2004 May 11;32(8): 2632 - 2641.

Comai、L、Young、K、Till、BJ、Reynolds、SH、Greene、EA、Codomo、CA、Enns、LC、Johnson、JE、 Burtner, C, Odden, AR, and Henikoff, S. 生态耕作技术在自然种群中DNA多态性的有效发现. Plant J. 2004 Mar;37(5): 778 - 786.

Greene, EA, Codomo, CA, Taylor, NE, Henikoff, JG, Till, BJ, Reynolds, SH, Enns, LC， Burtner, C, Johnson, JE, Odden, AR, Comai, L, and Henikoff, S. 拟南芥大规模反向基因筛选化学诱导突变谱. Genetics. 2003 Jun;164(2): 731 - 740.

Till, BJ, Reynolds, SH, Greene, EA, Codomo, CA, Enns, LC, Johnson, JE， Burtner, C，奥登，AR，杨，K，泰勒，NE，亨尼科夫，JG，科迈，L，和亨尼科夫，S. 大规模发现高通量TILLING诱导点突变. Genome Res. 2003 Mar;13(3): 524 - 530.